Dose-dependent Biphasic Activity of tRNA Synthetase-associating Factor, p43, in Angiogenesis
نویسندگان
چکیده
منابع مشابه
A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes.
An auxiliary factor of mammalian multi-aminoacyl-tRNA synthetases, p43, is thought to be a precursor of endothelial monocyte-activating polypeptide II (EMAP II) that triggers proinflammation in leukocytes and macrophages. In the present work, however, we have shown that p43 itself is specifically secreted from intact mammalian cells, while EMAP II is released only when the cells are disrupted. ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m207934200